Studies have shown that metolazone, a drug for hypertension, activates the mitochondrial repair mechanism in cells, helping to increase the body’s lifespan.
Although aging is not is a disease, scientists are looking for drugs that can slow down this process and weaken its negative effects on health. One of the factors of aging there is a decrease in the functionality of mitochondria, which perform the function of energy stations of cells. There is a mechanism in the body to repair these organelles called the mitochondrial unfolded protein response.
Researchers at Osaka City University studied the effects of various drugs on stimulating this process. In tests on several types of worms, scientists found that metolazone contributed to a noticeable increase in their lifespan, significantly standing out against the background approximately 3000 other tested drugs.
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They found that the hypertension drug, which has been known for over 50 years, has a strong effect on the HSP-6 gene (known as HSPA9 in humans), which is involved in activating the mitochondrial unfolded protein response..
Subsequent experiments with individual groups of human cells have also shown an increase in gene expression. As a result, the team hypothesized that the anti-aging effect of metolazone may also be present in mammals..
While more research will be needed to test the effect of the drug on longevity, this cheap and well-known drug has performed far better than all approved anti-aging drugs..
Recall that recently, scientists have transformed sugar molecules a universal antiviral drug.
text: Ilya Bauer, photo: Shutterstock