A team of researchers from India and France was able to achieve complete restoration of long-term memory in mice with Alzheimer’s disease using synthesized therapeutic molecules attached to carbon nanospheres.
Initially, scientists created a special substance that activates two enzymes (CBP and p300 histone acetyltransferases) that promote the regeneration of brain neurons and prevents their destruction. Their presence also activates several genes that are important for memory. During the tests, in the experimental mice, not only recovery of 81% of destroyed cells was observed, but also the formation of new connections, normalization of memory, and a decrease in the load on previous neurons..
However, despite the unique therapeutic properties, the molecules of the substance could not cross the blood-brain barrier and enter the brain, so the team began to look for a transportation solution. They became carbon spheres with a diameter of 400 nm, which are created using glucose..
The therapeutic molecules are attached to the surface of the nanospheres, with which they reach the necessary areas of the brain. The penetration effect is made possible by the fact that the carbon spheres partially retain the properties of glucose, which the cells feed on. Nonospheres with the drug reach the brain 48-72 hours after injection into the body and stay there for about 21 days.
In addition to treating Alzheimer’s disease, the technology can be used to combat other damage to neurons, memory, and neurodegradation. So far, the team JNCASR investigates the long-term effects of the ingredients on the body and the possible side effects of their use. In the future, they plan to launch their own startup..
Researchers at Northwestern St. Louis University are also working on tissue regeneration. They have developed a biocompatible implant that helps repair damaged peripheral nerves and decomposes completely in the body within a month..
text: Ilya Bauer, photo: hindipanda, Unsplash
Inside Alzheimer’s disease